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The Solution to Resistant Hypertension Treatment is Cold!


CRYOVASC´s Renal Freezer

Just One Cold Beam and
High-Blood Pressure is Gone.

The Most Powerful Blood-Pressure Drop Ever Measured in Renal Denervation.


CRYOVASC Renal Freezer

Maximum precision combined with a softer, tissue-sparing approach that is safer than anything before.

Most existing renal denervation systems use heat to destroy the nerves around the renal artery. Our Cryo-RDN technology works differently: we cool it down to very low, sub-zero temperatures.

The Cold Resistant Hypertension Treatment in Renal Denervation.

Our controlled cold treatment targets the renal nerves surrounding the artery in a precise and gentle way, without using heat.

Best of all, only one balloon inflation per renal artery is needed — making the procedure simpler, faster, and eliminating the need for repeated denervations.

Stylized geometric logo with interconnected hexagons forming a snowflake-like pattern on a black background.

Animal Study Published
Peer-Reviewed in JACC.


"Preclinical Evaluation of a
Novel Cryo Renal Denervation System"

Animal Study JACC March 2025

"In the porcine model, Cryo-RDN sufficiently ablated sympathetic nerves along renal arteries, demonstrating the safety and efficacy of the approach and the novel device."

"Cryoablation for Renal Denervation:
A Cool Alternative to Thermal Approaches?"

Editorial Comment JACC June 2025

"Their preclinical study in a porcine model demonstrates the feasibility and efficacy of a nitrous oxide–based cryoballoon system with a "1-inflation-only" approach that could reduce the multiple ablation points required for the RF or ultrasound RDN system. "

The Silent Killer: Hypertension.

Nearly 25% of the global population is affected by hypertension.

Of those patients, around 25% do not respond adequately to drug therapy and suffer from resistant hypertension. For these non-responders, the consequences are severe: a 20% higher risk of stroke, a 31% increase in intracerebral hemorrhage, and billions in additional healthcare costs worldwide.

Our cold RDN approach with the “Renal Freezer” represents a new therapeutic option for patients with resistant hypertension — designed to deliver a lasting treatment effect in a single, streamlined intervention.

Cold Is Changing Resistant Hypertension Treatment.

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