THE RENAL FREEZER: A NEW MEDTECH DEVICE FOR RENAL DENERVATION (IN DEVELOPMENT)
The cold way to treat resistant hypertension.
Our goal: just one cold beam and high-blood pressure is gone.
An investment of Germany’s VC fund High-Tech Gründerfonds
Our mission is to make hypertension treatable in a single renal denervation (RDN) procedure with cold, for a durable and long-lasting result.
THE PROBLEM
The silent killer 2 billion people can’t escape: hypertension is the world's number one chronic disease.
Hypertension (high blood pressure) is defined as ≥130/80 mmHg, and it silently damages the arteries over years, driving heart attacks, strokes and heart failure. Most people feel nothing until it is too late.
2B
People living with hypertension worldwide.
Deaths every year
10M+
In annual healthcare costs
€100B+
Drug resistance
In 25% of patients, medication simply does not work. 500 million people are left with no adequate option.
Compliance crisis
Even where drugs work, patients stop taking them and pressure surges back.
A 10 mmHg rise in systolic pressure is linked to a 20% higher stroke risk and a 31% greater risk of intracerebral hemorrhage.
THE EVIDENCE
Renal denervation. Interrupt the signal, drop the pressure.
Beyond the heart and blood vessels, the kidneys play a pivotal role in blood-pressure control. Overactive sympathetic nerves around the renal arteries keep pressure dangerously high.
Renal denervation (RDN) is a minimally invasive procedure: a catheter is guided through a small groin puncture into the renal arteries, where it ablates the overactive nerves from inside the vessel to interrupting the signal that drives hypertension.
RENAL ARTERY · NERVE ABLATION
This image is an adaptation of the original photograph by source: Catheter-Based Renal Denervation for Blood Pressure Reduction,
K. Rocha-Singh, Cath Lab Digest, Volume 17 -Issue 6 - June, 2009
THE TECHNOLOGY
Our cold treatment: the Renal Freezer.
We use controlled cooling using liquid N₂O to selectively deactivate the renal nerves.
Our unique cryo-balloon conforms to the vessel wall for highly efficient energy transfer, reaching a broad nerve area. Because our cold treatment is tissue-selective, it destroys nerve fibres while preserving the integrity of the vessel wall.
RENAL FREEZER · COLD ENERGY
THE EVIDENCE
Our animal study is published in JACC with outstanding results.
A peer-reviewed porcine study, validating renal denervation with cryo in one of cardiology's leading journals.
CONTACT
Get in touch.
Hypertension is one of the world’s largest unmet medical needs.
Join us in shaping the next generation of treatment – explore the investment opportunity.